Ketamine vs. TMS vs. Medication for Depression in North Idaho
- John M. Thurston, MD
- Sep 24, 2025
- 3 min read
Updated: Oct 8, 2025
For many people living with depression, finding the right treatment can be challenging. Medications may help some patients, but others experience little to no relief, even after trying multiple prescriptions. In Coeur d’Alene and throughout North Idaho, patients now have more advanced options, including
ketamine infusion therapy and Transcranial Magnetic Stimulation (TMS). Understanding how these treatments compare can help you make the best decision for your mental health.
At North Idaho Ketamine & TMS, we specialize in innovative, evidence-based treatments designed to support patients struggling with treatment-resistant depression. This guide compares ketamine, TMS, and traditional medications so you can make an informed choice.

How Traditional Antidepressant Medications Work
Traditional antidepressants, such as SSRIs and SNRIs, are often the first line of treatment for depression. These medications work by balancing neurotransmitters like serotonin and norepinephrine in the brain. While many patients find relief with medication, results can take weeks or even months, and some patients experience limited benefits or unwanted side effects.
Common considerations for antidepressants:
Time to effectiveness: Often several weeks before noticeable results
Potential side effects: Weight gain, fatigue, sexual dysfunction, and nausea
Medication management: Ongoing prescriptions and regular monitoring are usually required
Medications remain an important tool, but for those who do not respond to them, ketamine and TMS provide new hope.
What Is Ketamine Therapy?
Ketamine therapy uses low doses of ketamine administered intravenously in a controlled medical setting. It works differently from traditional antidepressants by targeting NMDA receptors and promoting neuroplasticity. This allows the brain to form new connections and reset patterns associated with depression.
Why patients consider ketamine therapy:
Rapid relief: Some patients notice improvement within hours or days
Effective for treatment-resistant depression: Especially for those who have not responded to other therapies
Additional benefits: Can also help with PTSD, anxiety, and chronic pain
Learn more about our approach to KETAMINE INFUSIONS THERAPY
What Is TMS Therapy?
Transcranial Magnetic Stimulation (TMS) is a non-invasive treatment that uses gentle magnetic pulses to stimulate areas of the brain involved in mood regulation. It promotes healthy brain activity without the use of systemic medications.
Why patients consider TMS therapy:
Non-invasive: No anesthesia or sedation required
Minimal side effects: Most patients resume normal activities immediately after treatment
Long-lasting results: Many patients maintain improvements even after therapy is complete
Proven effectiveness: Backed by strong clinical research for treatment-resistant depression
Learn more about our approach to TMS THERAPY
Comparing Ketamine, TMS, and Medications
Feature | Ketamine Therapy | TMS Therapy | Traditional Medications |
Treatment Type | IV infusion | Non-invasive brain stimulation | Oral or prescribed medication |
Time to Results | Hours to days | Weeks to months, gradual improvement | Weeks to months |
Ideal Candidates | Treatment-resistant depression, PTSD, anxiety | Treatment-resistant depression, OCD, PTSD | Mild to moderate depression |
Side Effects | Mild and temporary (e.g., dizziness) | Minimal (e.g., mild headache) | Possible weight gain, fatigue, nausea |
Session Frequency | Multiple infusions, spaced out | Usually 5 sessions per week for 4 to 6 weeks | Daily use required |
Medication Required | No ongoing medication | No ongoing medication | Yes |
This table can help you understand which approach might be right for you based on your symptoms and preferences.
Why Choose North Idaho Ketamine & TMS
At North Idaho Ketamine & TMS, we provide both ketamine therapy and TMS therapy under one roof, making us uniquely positioned to customize your treatment plan. We also offer CTK therapy, which combines TMS and ketamine for enhanced results in select patients.
Our team, led by Dr. John M. Thurston, provides compassionate, evidence-based care for individuals struggling with depression and related conditions. We are proud to partner with programs like the Patriot Power Up Program to support veterans and first responders in accessing these innovative therapies.
How to Get Started
If you are ready to explore your treatment options, here is how to take the next step:
Schedule your consultation — Book online or call our office
Discuss your goals — We will perform a thorough evaluation
Review your options — Learn whether ketamine, TMS, or a combined approach is right for you
Begin treatment — Start your customized care plan with our full support
For information on pricing and packages Ketamine Therapy Pricing and Packages TMS Therapy Pricing and Packages
Key Takeaways
Patients in Coeur d’Alene and across North Idaho now have access to multiple advanced treatment options for depression. While traditional medications remain valuable, ketamine therapy and TMS therapy are helping many people find relief when medications alone are not enough. At North Idaho Ketamine & TMS, we create individualized treatment plans that give you the best chance at lasting improvement.





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